Differences in the Functional Activity and Redox Homeostasis Between the Left and Right Adrenal Gland of Rats Exposed to Chronic Isolation Stress

Abstract The aim of this study was to examine whether there are differences in adrenomedullary function respect the left and right sides chronic stress conditions. We investigated how isolation (CSI 12 weeks) affected protein levels key enzymes involved adrenaline (A) synthesis (phenyl ethanolamine N-methyltransferase -PNMT), storage (vesicular monoamine transporters 2 - VMAT2) degradation (catechol-O-methyltransferase COMT), as well concentrations A an index for adrenal medulla. Also, we examined malondialdehyde (MDA), nuclear factor κB (NF-κB), activity catalase (CAT) parameters were quantified by Western blot analysis, assay enzymatic activity, CAT Research ELISA kits. found that CSI pro duced significantly increased PNMT protein, VMAT2 However, recorded COMT NF-κB, MDA decreased only Based on these results, it may be concluded is different